197 ENDOTHELIAL CELL SENESCENCE: THE ROLE OF SIRT6
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چکیده
منابع مشابه
Deacetylase SIRT6 deaccelerates endothelial senescence.
Vascular endothelial homeostasis is critical to health and is a significant factor in many human diseases. It is established that endothelial cell (EC) dysfunction is one of the earliest pathological steps in the initiation and progression of vascular diseases such as atherosclerosis and vascular remodelling. 3 How to maintain a healthy or repair an injured endothelial lining of the vasculature...
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Accumulating evidence has shown that diabetes accelerates aging and endothelial cell senescence is involved in the pathogenesis of diabetic vascular complications, including diabetic retinopathy. Oxidative stress is recognized as a key factor in the induction of endothelial senescence and diabetic retinopathy. However, specific mechanisms involved in oxidative stress-induced endothelial senesce...
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15 صفحه اولSIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence
AIMS Although endothelial cell senescence is known to play an important role in the development of cardiovascular pathologies, mechanisms that attenuate this process have not been extensively investigated. The aim of this study was to investigate whether SIRT6, a member of the sirtuin family of NAD(+)-dependent protein deacetylases/ADP-ribosyltransferases, protects endothelial cells from premat...
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ژورنال
عنوان ژورنال: Heart
سال: 2013
ISSN: 1355-6037,1468-201X
DOI: 10.1136/heartjnl-2013-304019.197